Protein Characterization Services

Contract Protein Characterization Services

Using state-of-the-art instrumentation and reliable analytical methods, UPP scientists, provide structural, physicochemical and biophysical characterization for biopharmaceutical products using various chromatography and mass spectrometry techniques. Leveraging our expertise and vast experience in monoclonal antibodies, bi/multi-specific antibodies, antibody-drug conjugates (ADCs), cellular and gene therapy products (e.g. AAV therapeutics), we provide protein analytics to support biopharmaceutical characterization in preclinical and clinical development phases for our clients.

Structural Characterization Services 

Molecular weight determination
Primary structure amino acid sequencing
N and C Terminal sequencing
Peptide mapping for post-translational modifications
Amino acid analysis
Disulfide bridge and free thiols analysis
Glycosylation and oligosaccharide analysis
Monosaccharide analysis
Coefficient of extinction
Characterization for size, charge and structural variants
Developability assessment

Biophysical and Physicochemical Testing Services

CE-SDS, iCIEF

Liquid chromatographic profiling

Tm, Tagg and particle size (DLS)

Edman degradation

Circular dichroism

FTIR

Intrinsic fluorescence

SEC-MALS